Children |
| 1. John Charles Spencer, b. 30 May 1782, Spencer House, London, Middlesex, England |
| 2. Sarah Spencer, b. 29 Jul 1787, Althorp, Northamptonshire, England |
| 3. Richard Spencer, b. 18 Oct 1789, Dollington, Durham, England |
| 4. Robert Cavendish Spencer, b. 24 Oct 1791, Althorp, Northamptonshire, England |
| 5. Harriet Spencer, b. 12 Mar 1793, Brinton, Northamptonshire, England |
| 6. Georgiana Charlotte Spencer, b. 13 Aug 1794, Wimbledon, Surrey, England |
+ | 7. Earl of Spencer Frederick Spencer, b. 1798 |
| 8. George Spencer, b. 21 Dec 1799, Althorp, Northamptonshire, England |
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