Karl married Princess of Nassau-Weilburg Wilhelmine Karoline on 05 Mar 1760 in S'gravenhage, Zuid Holland, Netherlands. Wilhelmine (daughter of Prince William of Orange, IV and Princess Royal of Orange Anne Hanover) was born on 28 Feb 1743 in Leeuwarden, Friesland, Netherlands; was christened on 10 Mar 1743 in Leeuwarden, Friesland, Netherlands; died on 06 May 1787 in Kirchheimbolanden, Pfalz, Bavaria. [Group Sheet] [Family Chart]

1. Prince of Nassau-Weilburg Georg Wilhelm Belgicus was born on 18 Dec 1760 in S'gravenhage, Zuid Holland, Netherlands; was christened on 13 Jan 1761 in S'gravenhage, Zuid Holland, Netherlands; died on 27 May 1762.
2. Prince of Nassau-Weilburg Wilhelm Ludwig Karl was born on 12 Dec 1761 in S'gravenhage, Zuid Holland, Netherlands; was christened on 20 Dec 1761 in S'gravenhage, Zuid Holland, Netherlands; died on 26 Apr 1770.
3. Princess of Nassau-Weilburg Marie Auguste Karoline was born on 05 Feb 1764 in S'gravenhage, Zuid Holland, Netherlands; was christened on 08 Feb 1764 in S'gravenhage, Zuid Holland, Netherlands; died on 20 Jan 1802.
4. Princess of Nassau-Weilburg Wilhelmine Luise was born on 28 Sep 1765 in S'gravenhage, Zuid Holland, Netherlands; was christened on 02 Oct 1765 in S'gravenhage, Zuid Holland, Netherlands; died on 10 Oct 1837 in Greiz, Reuss-Aeltere-Linie, Thuringia; was buried on 17 Oct 1837 in Greiz, Reuss-Aeltere-Linie, Thuringia.
5. Princess _____ Nassau-Weilburg was born on 15 Oct 1767 in S'gravenhage, Zuid Holland, Netherlands; was buried on 24 Oct 1767.
6. Prince of Nassau-Weilburg Friedrich Wilhelm was born on 25 Oct 1768 in S'gravenhage, Zuid Holland, Netherlands; was christened on 30 Oct 1768 in S'gravenhage, Zuid Holland, Netherlands; died on 09 Jan 1816 in Weilburg, Hessen-Nassau, Prussia; was buried in Weilburg, Hessen-Nassau, Prussia.
7. Karoline Luise Friederike Nassau-Weilburg was born on 14 Feb 1770 in Kirchheimbolanden, Pfalz, Bavaria; died on 08 Jul 1828 in Wiesbaden, Hessen-Nassau, Prussia.
8. Prince of Nassau-Weilburg Karl Ludwig was born on 19 Jul 1772 in Kirchheimbolanden, Pfalz, Bavaria; died on 27 Jul 1772.
9. Prince of Nassau-Weilburg Karl Friedrich Wilhelm was born on 01 May 1775 in Kirchheimbolanden, Pfalz, Bavaria; died on 11 May 1807.
10. Princess of Nassau-Weilburg Amalie Charlotte Wilhelmine was born on 06 Aug 1776 in Kirchheimbolanden, Pfalz, Bavaria; died on 19 Feb 1841 in Schaumburg, Hessen-Nassau, Prussia.
11. _____ Nassau-Weilburg was born in 1778 in Kirchheimbolanden, Pfalz, Bavaria; died in 1778.
12. _____ Nassau-Weilburg was born in 1779 in Kirchheimbolanden, Pfalz, Bavaria; died in 1779.
13. Princess of Nassau-Weilburg Henriette was born on 22 Apr 1780 in Kirchheimbolanden, Pfalz, Bavaria; died on 02 Jan 1857 in Kirchheim Unter Teck, Donaukreis, Whurttemburg; was buried on 07 Jan 1857 in Collegiate Church, Stuttgart, Neckarkreis, Whurttemburg.
14. _____ Nassau-Weilburg was born in Nov 1784 in Kirchheimbolanden, Pfalz, Bavaria.
15. _____ Nassau-Weilburg was born in Nov 1785 in Kirchheimbolanden, Pfalz, Bavaria; died in INFANT.