Friedrich married Charlotte Georgine Luise Mecklenburg Strelitz on 03 Sep 1785 in Hildburghausen, Saxe-Meiningen, Thuringia. Charlotte (daughter of Grand Duke of Mecklenburg-Strelitz Karl, II and Friederike Karoline Luise Hesse-Darmstadt) was born on 17 Nov 1769 in Hannover, Hannover, Prussia; died on 14 May 1818 in Hildburghausen, Sachsen-Meiningen, Thuringia; was buried in May 1818 in Friedhof, Hildburghausen, Sachsen Meiningen, Thuringia. [Group Sheet] [Family Chart]

1. Prince of Saxe Josef Georg Karl Friedrich was born on 12 Jun 1786 in Hildburghausen, Sachsen-Meiningen, Thuringia; died on 30 Jul 1786.
2. Charlotte Catharine Georgine Whurttemberg was born on 17 Jun 1787 in Hildburghausen, Sachsen-Meiningen, Thuringia; died on 12 Dec 1847 in Bamberg, Oberfranken, Bavaria.
3. Princess of Saxe Charlotte Auguste was born on 29 Jul 1788 in Hildburghausen, Sachsen-Meiningen, Thuringia; died on 29 Jul 1788.
4. Duke of Saxe-Altenburg Josef Georg Friedrich Ernst Karl was born on 27 Aug 1789 in Hildburghausen, Sachsen-Meiningen, Thuringia; died on 25 Nov 1868 in Altenburg, Saxe-Altenburg, Thuringia.
5. Princess of Saxe Luise Friederike Marie Karoline was born on 18 Jan 1791 in Hildburghausen, Sachsen-Meiningen, Thuringia; died on 25 Mar 1791.
6. Therese Charlotte Luise Saxe-Hildburghausen was born on 08 Jul 1792 in Hildburghausen, Sachsen-Meiningen, Thuringia; died on 26 Oct 1854 in Mhunchen, Oberbayern, Bavaria; was buried in St. Boniface Church, Mhunchen, Oberbayern, Bavaria.
7. Princess of Saxe Charlotte Luise Friederike A. was born on 28 Jan 1794 in Hildburghausen, Sachsen-Meiningen, Thuringia; died on 6 Apr 1825 in Biebrich, Hessen-Nassau, Prussia; was buried in Weilburg, Hessen-Nassau, Prussia.
8. Prince of Saxe Franz Friedrich Karl Ludwig Georg was born on 13 Apr 1795 in Hildburghausen, Saxe-Meiningen, Thuringia; died on 28 May 1800.
9. Duke of Saxe-Altenburg Georg Karl Friedrich Franz was born on 24 Jul 1796 in Hildburghausen, Saxe-Meiningen, Thuringia; died on 3 Aug 1853 in Hummelshain Castle, S-Altn, Thrn.
10. Prince of Saxe Friedrich Wilhelm Karl Josef L. was born on 4 Oct 1801 in Hildburghausen, Saxe-Meiningen, Thuringia; died on 1 Jul 1870.
11. Prince of Saxe Maximilian Karl Adolf Heinrich was born on 19 Feb 1803 in Hildburghausen, Saxe-Meiningen, Thuringia; died on 29 Mar 1803.
12. Eduard Karl Saxe-Hildburghausen-Altenburg was born on 3 Jul 1804 in Hildburghausen, Saxe-Meiningen, Thuringia; died on 16 May 1852 in Munchen, Oberbayern, Bavaria; was buried on 20 May 1852 in Altenburg, Saxe-Altenburg, Thuringia.