Isabelle married Prince of Nassau-Weilburg Friedrich Wilhelm on 31 Jul 1788 in Hachenburg, Hessen-Nassau, Prussia. Friedrich (son of Prince of Nassau-Weilburg Karl Christian and Princess of Nassau-Weilburg Wilhelmine Karoline) was born on 25 Oct 1768 in S'gravenhage, Zuid Holland, Netherlands; was christened on 30 Oct 1768 in S'gravenhage, Zuid Holland, Netherlands; died on 09 Jan 1816 in Weilburg, Hessen-Nassau, Prussia; was buried in Weilburg, Hessen-Nassau, Prussia. [Group Sheet] [Family Chart]

1. Duke of Nassau Wilhelm Georg August Heinrich Nassau-Weilburg was born on 14 Jun 1792 in Kirchheimbolanden, Pfalz, Bavaria; died on 20 Aug 1839 in Kissingen, Unterfranken, Bavaria; was buried in Weilburg, Hessen-Nassau, Prussia.
2. Princess of Nassau Auguste Luise Wilhelmine was born on 5 Jan 1794 in Weilburg, Hessen-Nassau, Prussia; died on 11 Apr 1796; was buried in Capuchin Church, Wien, Wien, Austria.
3. Henriette Alexandrina Frederika Nassau-Weilburg was born on 30 Oct 1797 in Schloss Eremitage Bei Bayreuth, O-Frnk, Bavaria; died on 29 Dec 1829 in Wien, Wien, Austria; was buried in Toscanagruft, Wien, Wien, Austria.
4. Prince of Nassau Friedrich Wilhelm was born on 15 Dec 1799 in Schloss, Eremitage Bei Bayreuth, Oberfranken, Bavaria; died on 6 Jan 1845 in Wien, Wien, Austria.